Roche’s lampalizumab phase II data shows benefit in patients with the advanced form of dry age-related macular degeneration.

Macular degeneration.

Phase II data met its primary efficacy endpoint in slowing the progression of geographic atrophy lesions in patients with advanced dry age-related macular degeneration.

Roche (SIX: RO, ROG; OTCQX: RHHBY) today announced positive phase II results from the MAHALO study demonstrating that lampalizumab (also referred to as anti-factor D) showed a 20.4 percent reduction rate in the area of geographic atrophy at 18 months in patients with this advanced form of dry age-related macular degeneration (AMD).
The MAHALO phase II data also showed no unexpected or unmanageable serious adverse events associated with lampalizumab.

These data were presented at the 31st Annual Meeting of the American Society of Retina Specialists in Toronto, Ontario, Canada.

Lampalizumab is being investigated to determine its effect on the progression of GA associated with advanced dry AMD. The molecule is an antigen-binding fragment (Fab) of a humanised, monoclonal antibody directed against complement factor D. Complement factor D is a rate-limiting enzyme involved in the activation of the alternative complement pathway (ACP).

The ACP is a component of the immune system's natural defence against infections. Genetic polymorphisms as well as hyperactivity of the ACP have been implicated in the development of AMD including GA.

Basel, 27 August 2013.


Новости офтальмологии Ophthalmology news portal organum-visus: раздел международного офтальмологического портала Орган зрения – The International Ophthalmic portal

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Материал подготовил Голубев Сергей Юрьевич.